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  Most popular articles (Since August 26, 2016)

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Hidradenocarcinoma presenting with multiple site metastases
Kriti Chauhan, Monika Garg, Eshita Dadwal
January-June 2017, 6(1):11-13
Hidradenocarcinoma also known as malignant nodular hidradenoma or clear cell hidradenocarcinoma are very uncommon skin adnexal tumors of sweat gland origin known to have a high potential for local reccurence and metastasis. Histologically it is a challenge to diagnose because it very commonly mimics several metastatic visceral malignancies and other non-aggressive skin adnexal tumors. We highlight here the importance of timely diagnosis of hidradenocarcinoma and its differentiation from other look alike because of its poor prognosis and uncertain response to chemotherapy and radiotherapy.
  8,558 1,023 -
Cytomorphometric analysis of exfoliated buccal mucosal cells in smokers and tobacco chewers
Abhishek Singh Nayyar, B Kartheeki, Pallavi Sinha, Kazi Abdullah Zakaria, Channe Rashmi Chandrakant, Abhay Kulkarni
January-June 2017, 6(1):1-4
Aims and Objectives: Exfoliative cytology is a minimally invasive procedure that has been used for the detection of early changes in clinically normal oral mucosa of tobacco users. This study highlights the cause-effect relationship between tobacco usage in varied forms and the structural cellular and nuclear alterations in different age groups. Materials and Methods: This study was conducted with different age groups who were tobacco users as a planned, cross-sectional study. Results: The results of the study revealed that the mean nuclear diameter (ND) and cytoplasmic diameter (CD) showed a statistically significant difference in the control group and in smokers and tobacco chewers. Conclusion: Increase in ND and decreased CD, as well as an altered nucleo-cytoplasmic ratio, appear to be due to chronic tobacco usage and cytomorphometric analysis can be used to detect these cellular and subcellular alterations at an early enough stage before actually a frank, morphological change can be appreciated in relation to the oral mucosa.
  8,496 932 -
Oral pulse or hyaline ring granuloma: A bird's eye view
Arpan K Shah
January-June 2017, 6(1):5-7
Pulse granuloma or hyaline ring granulomas as frequently encountered while histopathological examination of various oral as well as extraoral lesions. There was a great deal of uncertainty about the pathogenesis of these structures. Many confusing terminologies were also suggested and used for pulse granulomas. However, now it is clear that pulse granuloma is fundamentally a lesion arising due to chronic granulomatous inflammation in response to implantation of foreign particles in the submucosal connective tissue. Appearance of multiple pulse granulomas may create diagnostic confusion. The purpose of this paper is an attempt to revisit the clarified pathogenesis and terminology of pulse granulomas.
  7,820 898 -
Congenital lateral synechia with sacrococcygeal teratoma
Aditya Pratap Singh, Vinay Mathur, Ramesh Tanger, Arun Kumar Gupta
January-June 2017, 6(1):8-10
The presence of oral synechia along with sacrococcygeal teratoma (SCT) is a first case in the literature reported to date. We encountered a case of SCT accompanied by congenital lateral oral synechia without cleft palate. It was asymptomatic and accidental finding. It was resolved spontaneously. It may be considered Type 6 as isolated lateral synechia with extending from hard palate to the lateral part of the tongue.
  7,155 767 -
Management of oral candidiasis: A review
Irfana P K, Suganya Panneer Selvam
January-June 2019, 8(1):6-10
Candidiasis oral candidosis is one of the most common human opportunistic fungal infections of the oral cavity. The candidia infection may range from nonlife threatening superficial mucocutaneous disorders to invasive disseminated disease involving multiple organs. The treatment after confirmation of the diagnosis should include recognizing and eliminating the underlying causes, such as ill-fitting dentures, history of medications, immunological and endocrine disorders, nutritional deficiency states, and prolonged hospitalization. This pathology has a wide variety of treatment that has been studied until these days. After searching the latest articles about the treatment of candidiasis, it can be concluded that the incidence depends on the type of candidiasis and the virulence of the infection. Although nystatin and amphotericin b are the drugs used the most locally, fluconazole oral suspension is proving to be a very effective drug in the treatment of oral candidiasis. In certain high-risk groups, antifungal prophylaxis reduces the incidence and severity of infection. The prognosis is good in the great majority of cases.
  953 77 -
“Pigmented pilomatricoma”: A rare histopathological variant
Neeti Goyal, Ritu Mehta, Arun Gupta, Kunal Tiwari
July-December 2018, 7(2):17-19
Pilomatricoma is one of the common cutaneous benign adnexal tumors but the pigmented variant is rare among them. This is a case report of pigmented pilomatricoma in a young girl which has grown as a swelling over the supraclavicular region for 3 months and the histopathological features include basaloid cells and eosinophilic shadow cells with melanin deposition, calcification, and foreign body type giant cells.
  918 90 -
Subcutaneous cartilaginous choristoma of neck: A rare entity
Sonu Kalyan, Nitesh Kumari
January-June 2018, 7(1):8-11
The term “choristoma” refers to a hamartomatous tumor-like lesion that is composed of normal tissue in an abnormal location Most of the cartilaginous choristomas involve the tongue. These lesions are very rarely seen in the neck. We present a case report of an 8-year-old child presenting with a swelling on the left lower third of the neck anterior and lateral to the left sternocleidomastoid muscle in the subcutaneous plane. Swelling was present as childhood and progressively increased in size. Surgical excision was done and the specimen was sent for histopathological evaluation. Histopathological examination showed a circumscribed nodule of hyaline cartilage separated from the adjacent subcutaneous tissue and overlying skin by a thin fibrous connective tissue. Excision of the lesion including perichondrium and surrounding soft tissue is considered as curative. Removal of the perichondrium is very essential for avoiding recurrences, because perichondrium may have the capacity to develop a new cartilage.
  861 74 -
Morphological features in granulomatous mastitis: A window to the etiopathogenesis
Ravi Pratap Singh, Meetu Agrawal, Neha Kwatra Madan, Charanjeet Ahluwalia, Megha Tandon
January-June 2018, 7(1):1-7
Background: Granulomatous mastitis holds a special place amongst the various non-neoplastic lesions of breast. Most granulomas at various sites are thought to be and turn out to be tubercular, especially in a high tuberculosis prevalence country. However, a physiologically dynamic organ-like breast can have granulomas due to various causes, which have different therapeutic implications. Further, these lesions are usually mass-forming and close mimickers of malignancy. A careful analysis of histopathology can provide important clues to the etiopathogenesis. Aims: The aim of this study was to perform a detailed histopathological examination of cases of granulomatous mastitis and correlate it with clinical characteristics and follow-up data wherever applicable. Materials and Methods: A retrospective analysis of cases retrieved was carried out by two pathologists (RPS and MA). The morphological details were analyzed against the clinical, surgical, and follow-up data. Results and Conclusion: With careful analysis, the nature of constituent cells, relative proportion of cells and associated pathological findings can provide a clue as to the etiology of granulomas.
  844 83 -
Solitary fibrous tumor of the pelvis: A case report
Kusum D Jashnani, Jyothi B Shetty, Yi Ching Ling
July-December 2018, 7(2):22-25
Solitary fibrous tumor (SFT) is a rare mesenchymal neoplasm most commonly seen in the pleura. Rarely they can occur at extrapleural sites. SFT of the pelvis is rare with very few cases reported in the literature. We report a case of a 35-year-old female who presented with complaints of pain in abdomen for the last 1 year. Computed tomography revealed a large mass lesion in the pelvis measuring 15.9 × 12 × 13.8 cm extending up to the L4-L5 level. Bilateral ovaries were not seen separately. Histopathological examination of the resected specimen revealed an SFT.
  835 76 -
Sacrococcygeal teratoma showing pigmented epithelium: A case report
Aditya P Singh, Arun K Gupta, Maryem Ansari, Ramesh Tanger, Dinesh K Barolia
July-December 2018, 7(2):20-21
Teratoma may comprise either well-differentiated or primitive tissue. The tumor is diagnosed as an immature teratoma if there are areas of immature tissue in the stromal, epithelial, or neural component. The ectodermal components typically include squamous epithelium and neural tissue. We are presenting here a case of sacrococcygeal teratoma with pigmented epithelium on histopathology in a newborn female child.
  802 72 -
Heterotopic cartilage in endocervical polyp: A rare occurrence
Divya Sethi, Sangeeta Lamba, Annu Nanda, Shilpi More
January-June 2018, 7(1):12-13
Cartilaginous metaplasia in uterine cavity is a known entity, but such a presence is extremely rare in the endocervical polyps. The importance lies in differentiating it from mixed mesodermal tumour and retained foetal parts by taking a detailed history and thorough histopathological examination. We hereby present a case of a 31-year-old female presenting with bleeding per vaginum for 1 year who was then operated for polypectomy and on histopathological examination revealed areas of cartilaginous differentiation. Only two cases of such type have been reported in the literature to the best of our knowledge.
  802 68 -
Papillary carcinoma thyroid evolving within struma ovarii: An unusual occurrence
Shagufta Qadri, Asfa Shams, Kiran Alam, Sarah Irfan
January-June 2019, 8(1):11-15
Struma ovarii is a monodermal variant of ovarian teratoma. It is a very rare, germ cell tumor of the ovary, constituting less than 1% of all ovarian tumors. Thyroid tissue is the predominant element, constituting more than 50% of the total. Thyroid-type carcinoma arising in struma ovarii is a rare finding, of which papillary carcinoma being more common, followed by follicular carcinoma and a newer entity termed as highly differentiated follicular carcinoma of ovarian origin. A case of 48-year-old female presented with complaints of acute lower abdominal pain and vaginal bleeding. Imaging showed a solid cystic mass in left adnexa whereas right adnexa was unremarkable. Left salpingo-oophorectomy was performed. Histopathological examination and subsequent immunohistochemistry revealed struma ovarii with neoplastic transformation into papillary thyroid carcinoma. Malignant struma ovarii is difficult to diagnose clinicoradiologically and is mostly discovered incidentally, with only handful of cases published in the literature.
  760 80 -
Cellular senescence due to physical inactivity: A review
Sangavi Ramesh, Abilasha Ramasubramanian, Suganya Panneer Selvam
January-June 2019, 8(1):1-5
Fundamental building blocks of our bodies are called as cells. Cellular changes play a major role in the ageing process. Cellular senescence is a process where there is inability of the cells to proliferate due to loss of replicative or growth potential. Physical inactivity is the absence of any movement produced by muscles of body, which requires energy. Various molecular mechanisms are responsible for cellular senescence. One important factor is telomere, which protects chromosome and is chiefly responsible for the replicative process. Physical activity is found to be associated with reduced disease risk and increased longevity through various cellular and molecular mechanisms. However, evidences relating to cellular senescence and physical inactivity are found in sparse. This review aims to discuss the importance of physical activity and role of telomere in senescence and other aging processes.
  757 64 -
Applicability of ‘simple smartphone adapter for digital photomicrography’ in reducing operator effort in photomicrography
Himel Mondal, Shaikat Mondal
January-June 2018, 7(1):14-15
  622 65 -
Transitional morphology spill-out in high-grade ovarian serous carcinoma: Dilemmas and disputes in diagnosis
Meetu Agrawal, Jyoti Singh
July-December 2018, 7(2):26-27
  604 44 -
Solitary plasmacytoma of maxilla: Rare case report
Sandhya Sundar, Pratibha Ramani, Gheena Ranjith, Abilasha Ramasubramanian
January-June 2019, 8(1):16-18
Solitary plasmacytomas are rare group of neoplasms accounting for less than 5% of plasma cell dyscrasia. Here in, we report an unusual case of solitary plasma cell neoplasm in the maxilla in a 43-year-old female patient. Careful clinical and pathological evaluation revealed the isolated tumor of the plasma cells with absence of multiple bones and other extra-oral tissue involvement. As this isolated lesion has increased propensities to transform to its systemic counterpart, malignant melanoma—a constant, periodic follow-up is necessitated.
  458 69 -