International Journal of Histopathological Interpretation

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Hidradenocarcinoma also known as malignant nodular hidradenoma or clear cell hidradenocarcinoma are very uncommon skin adnexal tumors of sweat gland origin known to have a high potential for local reccurence and metastasis. Histologically it is a challenge to diagnose because it very commonly mimics several metastatic visceral malignancies and other non-aggressive skin adnexal tumors. We highlight here the importance of timely diagnosis of hidradenocarcinoma and its differentiation from other look alike because of its poor prognosis and uncertain response to chemotherapy and radiotherapy.

Aims and Objectives: Exfoliative cytology is a minimally invasive procedure that has been used for the detection of early changes in clinically normal oral mucosa of tobacco users. This study highlights the cause-effect relationship between tobacco usage in varied forms and the structural cellular and nuclear alterations in different age groups. Materials and Methods: This study was conducted with different age groups who were tobacco users as a planned, cross-sectional study. Results: The results of the study revealed that the mean nuclear diameter (ND) and cytoplasmic diameter (CD) showed a statistically significant difference in the control group and in smokers and tobacco chewers. Conclusion: Increase in ND and decreased CD, as well as an altered nucleo-cytoplasmic ratio, appear to be due to chronic tobacco usage and cytomorphometric analysis can be used to detect these cellular and subcellular alterations at an early enough stage before actually a frank, morphological change can be appreciated in relation to the oral mucosa.

Pulse granuloma or hyaline ring granulomas as frequently encountered while histopathological examination of various oral as well as extraoral lesions. There was a great deal of uncertainty about the pathogenesis of these structures. Many confusing terminologies were also suggested and used for pulse granulomas. However, now it is clear that pulse granuloma is fundamentally a lesion arising due to chronic granulomatous inflammation in response to implantation of foreign particles in the submucosal connective tissue. Appearance of multiple pulse granulomas may create diagnostic confusion. The purpose of this paper is an attempt to revisit the clarified pathogenesis and terminology of pulse granulomas.

The presence of oral synechia along with sacrococcygeal teratoma (SCT) is a first case in the literature reported to date. We encountered a case of SCT accompanied by congenital lateral oral synechia without cleft palate. It was asymptomatic and accidental finding. It was resolved spontaneously. It may be considered Type 6 as isolated lateral synechia with extending from hard palate to the lateral part of the tongue.

Online since 26^th Aug, 2016